Role of adrenal cortical function in toxicity of polyriboinosinic-polyribocytidylic acid and its component homopolymers.
نویسندگان
چکیده
Adrenalectomized rats are 1000 times more sensitive to lethal effects of the double-stranded complex polyriboinosinic.polyribocytidylic acid than intact rats. They are protected from such lethal effects by corticosterone. The complex can rapidly induce diffuse, severe necrosis of villous epithelium in small intestine without damage in crypts. Injection of the individual homopolymers, polyriboinosinic acid and polyribocytidylic acid, separately but in rapid succession is at least as lethal as injection of the complex.
منابع مشابه
Positive Limulus amoebocyte lysate reactions with polyriboinosinic acid x polyribocytidylic acid.
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ورودعنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 67 1 شماره
صفحات -
تاریخ انتشار 1970